각화낭치성종양의 이장상피에서 Bcl-2 발현양상과 임상지표

이인혁; 최소영; 박지훈; 김진수

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각화낭치성종양의 이장상피에서 Bcl-2 발현양상과 임상지표
Expression of Bcl-2 in the epithelial lining and clinical findings of keratocystic odotogenic tumor

대한구강악안면외과학회지 2011년 37권 3호 p.161 ~ 168

이인혁, 최소영, 박지훈, 김진수,

소속 상세정보

이인혁 ( Lee In-Hyuk ) - 경북대학교 치의학전문대학원 구강악안면외과학교실
최소영 ( Choi So-Young ) - 경북대학교 치의학전문대학원 구강악안면외과학교실
박지훈 ( Park Ji-Hoon ) - 경북대학교 치의학전문대학원 구강악안면외과학교실
김진수 ( Kim Chin-Soo ) - 경북대학교 치의학전문대학원 구강악안면외과학교실

KMID : 0355620110370030161

Abstract

Purpose: The odontogenic keratocysts demonstrated a high recurrence rate and a biologically aggressive nature. This might be due to unknown factors inherent in the epithelium or enzymatic activity in the fibrous wall. Bcl-2 protein is characterized by its ability to inhibit apoptosis. The aim of this study was to evaluate the expression and distribution of bcl-2 in the OKC?, its possible relationship with the tumorous characteristics, such as the aggressive nature and high recurrence rate, and its usefulness to differentiate OKC? from dentigerous cysts.

Material and Method : Formalin fixed paraffin-embedded tissue sections of 53 OKC?, and 44 dentigerous cyst were immunohistochemically analyzed quantitatively for the immunoreactivity of the bcl-2 protein with i-solution.

Results: More Bcl-2 expression was observed in the OKC? (mean34.387%) than dentigerous cyst (mean11.144%) with statistical significance (P＜0.001). Seventeen and 15 of the 32 OKC? in this study showed positivity in the basal layer and basal/suprabasal layers, respectively. In dentigerous cyst, 2 of 3 showed positivity in the basal cell layer.

Conclusion: Considering that bcl-2 over expression may lead to the increased survival of epithelial cells, this study demonstrated a possible relationship between the aggressive nature of OKC and the intrinsic growth potential of its lining epithelium. Furthermore, the basal/suprabasal distribution of bcl-2 positive cells was observed in some OKC?, which might have a significant impact on the behavior of cysts. The bcl-2 expression of OKC? can be useful for differentiating OKC? from dentigerous cysts.